90-day savings offer

You may pay as little as $10 for either a 30-day or 90-day prescription.*

Learn more

*Only commercially insured patients are eligible for the TRINTELLIX Savings Card. The TRINTELLIX Savings Card cannot be used by patients in federal, state, or government-funded healthcare programs or by cash patients. Maximum savings of $100 on a 30-day or $300 on a 90-day prescription. See Savings Card for Eligibility Requirements and Terms & Conditions.

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*Only commercially insured patients are eligible for the TRINTELLIX Savings Card. The TRINTELLIX Savings Card cannot be used by patients in federal, state, or government-funded healthcare programs or by cash patients. Maximum savings of $100 on a 30-day or $300 on a 90-day prescription. See Savings Card for Eligibility Requirements and Terms & Conditions.

Important Safety Information Prescribing Information Medication Guide For Healthcare Professionals
Important Safety Information Prescribing Information Medication Guide For Healthcare Professionals
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Savings and support

Personalized support. That helps.

Patient portrayal.

Sign up for savings*

*All TRINTELLIX patients can join the tAccess Support Program. Only commercially insured patients are eligible for the TRINTELLIX Savings Card. The TRINTELLIX Savings Card cannot be used by patients in federal, state, or government-funded healthcare programs or by cash patients. See Savings Card for Eligibility Requirements and Terms & Conditions.


†Maximum savings of $100 on a 30-day or $300 on a 90-day prescription. Must meet eligibility requirements.

Your personalized savings and support program

Enroll now to receive savings* and support at no cost to you.

tAccess Support Program logo

A support program built to partner with you as you start your treatment with TRINTELLIX (vortioxetine).

Customize your journey with support tools like:

Savings Card*

Pay as little as $10 for a 30- or 90-day prescription.† Maximum savings of $100 on a 30-day or $300 on a 90-day script. Must meet eligibility requirements.

Mobile Wallet*

Download your Savings Card and add it to your mobile wallet for your next refill. Must meet eligibility requirements.

Informative emails

Receive emails with tools to help empower you to have meaningful discussions with your doctor.

Inspiring texts and refill reminders when needed

Helpful messages and medication refill reminders sent to help you along the way.

Chats with a tAccess advisor

Call to receive information about the Savings Card and other support features (1-844-654-TRIN), 8:00 am – 8:00 pm EST M-F.

*All TRINTELLIX patients can join the tAccess Support Program. Only commercially insured patients are eligible for the TRINTELLIX Savings Card. The TRINTELLIX Savings Card cannot be used by patients in federal, state, or government-funded healthcare programs or by cash patients. See Savings Card for Eligibility Requirements and Terms & Conditions.


†Maximum savings of $100 on a 30-day or $300 on a 90-day prescription. Must meet eligibility requirements.

What to do next, if you are eligible:

Need a Savings Card?

Sign up for savings

Have a Savings Card?

Activate your card

Lost your Savings Card?

Get replacement card
Help At Hand: Patient Assistance Within Reach

Need help affording your prescription?

Visit Takeda Help At Hand to learn more.

Mail-in rebate

Patient mail-in rebate forms and information on eligibility and how to complete and submit are available at www.patientrebateonline.com.
You may also request one by calling 1-866-279-0287.

Next page: Resources

Frequently asked questions

  • How do I register for the TRINTELLIX Savings Card?

    If eligible, you can register for the TRINTELLIX Savings Card here. If you are having trouble signing up online or have questions about eligibility requirements, you can also call 1-866-279-0287 to register.

  • Am I eligible for the TRINTELLIX Savings Card?

    The TRINTELLIX Savings Card offer cannot be used if you are a beneficiary of, or any part of your prescription is covered by: (1) any federal, state, or government-funded healthcare program (for example, Medicare, Medicaid, TRICARE), including a state pharmaceutical assistance program (the Federal Employees Health Benefits (FEHB) Program is not a government-funded healthcare program for purposes of this offer), (2) the Medicare Prescription Drug Program (Part D), or if you are currently in the coverage gap, or (3) insurance that is paying the entire cost of the prescription. Patient must be age 18 or older and have a valid prescription for TRINTELLIX. Cash patients are not eligible for the TRINTELLIX Savings Card.

  • How do I activate and use my Savings Card?

    If you’re an eligible patient signing up for a TRINTELLIX Savings Card online, you will receive your activated card online immediately. You can print the Savings Card and use it right away. If you’re having trouble activating your Savings Card online, please call 1-866-279-0287 to activate it.

    If you received a TRINTELLIX Savings Card from your healthcare professional in the brochure, you can activate it here, or call 1-866-279-0287. You will be asked for the ID number on the card.

    Once you’ve activated your TRINTELLIX Savings Card, take your prescription and your savings card to your pharmacist.*

    *Must meet eligibility requirements, and subject to a maximum savings amount of $100 per 30-day or $300 per 90-day prescription. See savings card for Eligibility Requirements and Terms & Conditions.

  • What are the benefits of the TRINTELLIX Savings Card?

    With the TRINTELLIX Savings Card, eligible patients can save on TRINTELLIX prescriptions and refills. You also get free access to the TRINTELLIX Support Program, tAccess, which provides support for people with MDD.

    See "Am I eligible for the TRINTELLIX Savings Card?" above.

  • What should I expect to receive in the tAccess Support Program?

    The tAccess Support Program is personalized support for patients on TRINTELLIX therapy. The purpose of the program is to help patients stay on track with their treatment as directed by their healthcare professional.

    Patients who enroll in the tAccess Support Program can expect to receive:

    • Savings Card* - pay as little as $10 for a 30- or 90-day prescription. Maximum savings of $100 on a 30-day or $300 on a 90-day script. Must meet eligibility requirements.
    • Mobile Wallet* - download your Savings Card and add it to your mobile wallet for your next refill. Must meet eligibility requirements.
    • Informative emails - Receive emails with tools to help empower you to have meaningful discussions with your doctor.
    • Inspiring texts and refill reminders when needed - Helpful messages and medication refill reminders sent to help you along the way.
    • Chats with a tAccess advisor - Call to receive information about the Savings Card and other support features (1-844-654-TRIN), 8:00 am – 8:00 pm EST M-F.

    *All TRINTELLIX patients can join the tAccess Support Program. Only commercially insured patients are eligible for the TRINTELLIX Savings Card. The TRINTELLIX Savings Card cannot be used by patients in federal, state, or government-funded healthcare programs or by cash patients. See Savings Card for Eligibility Requirements and Terms & Conditions.

  • My pharmacy is having difficulty processing my Savings Card, or cannot process my Savings Card. Can I still receive savings?

    If the pharmacy has difficulty processing your card, have the pharmacy follow the steps on the back of your TRINTELLIX Savings Card. The pharmacy can also call 1-866-279-0287 for processing questions.

    If eligible and your pharmacist cannot process your card, or doesn’t accept your card and you’ve already paid for your prescription, please visit www.patientrebateonline.com and follow the instructions for savings. If you need further information, call 1-866-279-0287.

  • I've already paid for my prescription of TRINTELLIX. Is there a mail-in rebate available?

    Patient mail-in rebate forms for eligible patients and information on how to complete and submit them are available at www.patientrebateonline.com. You may also request one by calling 1-866-279-0287.

  • Who can I contact for general questions about the TRINTELLIX Savings Card, such as getting a replacement card?

    For general information about TRINTELLIX Savings Cards, including information for getting a replacement card, call 1-866-279-0287.

  • If I don't qualify for the TRINTELLIX Savings Card, are there any assistance programs available to help cover my prescription?

    Help At Hand is a patient assistance program that provides access to medicine for eligible patients with financial need. Visit Help At Hand to request an application. Restrictions apply.

IMPORTANT SAFETY INFORMATION About TRINTELLIX

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Suicidal Thoughts & Actions

TRINTELLIX and other antidepressants may increase suicidal thoughts and actions in some people 24 years of age and younger, especially within the first few months of treatment or when the dose is changed. TRINTELLIX is not for use in children under 18. Depression or other mental illnesses are the most important causes of suicidal thoughts or actions. Pay close attention to any changes, especially new or sudden changes in mood, behavior, thoughts, or feelings. Call your doctor or get emergency help right away if you have symptoms such as suicidal thoughts or actions, impulsivity, aggressive or violent actions, depression, anxiety or panic attacks, agitation, restlessness, anger, irritability, trouble sleeping, an increase in activity or talking, or other unusual changes in behavior or mood; especially if they are new, worse, or worry you.

Who should not take TRINTELLIX?

Do not start or take TRINTELLIX if you:

  • are allergic to vortioxetine or any of the ingredients in TRINTELLIX
  • take a Monoamine Oxidase Inhibitor (MAOI)
  • have stopped taking an MAOI in the last 14 days
  • are being treated with the antibiotic linezolid or intravenous methylene blue

Do not start taking an MAOI for at least 21 days after you stop treatment with TRINTELLIX.

What should I tell my doctor before taking TRINTELLIX?

Before taking TRINTELLIX, tell your doctor:

  • about all your medical and other health conditions
  • if you are pregnant or plan to become pregnant, since TRINTELLIX may harm your unborn baby. Taking TRINTELLIX during your third trimester may cause your baby to have withdrawal symptoms after birth or to be at increased risk for a serious lung problem at birth. Tell your doctor right away if you become or think you are pregnant while taking TRINTELLIX.
  • if you are breastfeeding or plan to breastfeed, since it is not known if TRINTELLIX passes into your breast milk

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements, since TRINTELLIX and some medicines may cause serious side effects (or may not work as well) when taken together. Especially tell your doctor if you take: medicines for migraine headache called triptans; tricyclic antidepressants; opioids (such as fentanyl and tramadol); lithium; tryptophan; buspirone; St. John’s Wort; medicines that can affect blood clotting such as aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), warfarin; and diuretics.

What are the possible side effects of TRINTELLIX?

TRINTELLIX may cause serious side effects, including:

  • Serotonin syndrome: A potentially life‐threatening problem that can happen when you take TRINTELLIX with certain other medicines. Call your doctor or go to the nearest emergency room right away if you have any of the following signs and symptoms of serotonin syndrome: agitation; seeing or hearing things that are not real; confusion; coma; fast heart beat; changes in blood pressure; dizziness; sweating; flushing; high body temperature; shaking, stiff muscles, or muscle twitching; loss of coordination; seizures; nausea, vomiting, diarrhea.
  • Increased risk of bleeding: Taking TRINTELLIX with aspirin, NSAIDs, warfarin or blood thinners may add to this risk. Tell your doctor right away about any unusual bleeding or bruising.
  • Manic episodes: Manic episodes may happen in people with bipolar disorder who take TRINTELLIX. Symptoms may include: greatly increased energy; racing thoughts; unusually grand ideas; talking more or faster than usual; severe problems sleeping; reckless behavior; excessive happiness or irritability.
  • Discontinuation syndrome: Suddenly stopping TRINTELLIX may cause you to have serious side effects including: nausea; sweating; changes in your mood; irritability and agitation; dizziness; electric shock feeling; tremor; anxiety; confusion; headache; tiredness; problems sleeping; hypomania; ringing in your ears; seizures.
  • Eye problems: TRINTELLIX may cause a type of eye problem called angle-closure glaucoma in people with certain other eye conditions. You may want to undergo an eye examination to see if you are at risk and receive preventative treatment if you are. Call your doctor if you have eye pain, changes in your vision, or swelling or redness in or around the eye.
  • Low levels of salt (sodium) in your blood: Low sodium levels in your blood that may be serious and may cause death can happen during treatment with TRINTELLIX. Elderly people and people who take certain medicines may be at a greater risk for developing low sodium levels in your blood. Signs and symptoms may include headache; difficulty concentrating; memory changes; confusion; weakness and unsteadiness on your feet which can lead to falls. In more severe or more sudden cases, signs and symptoms include: seeing or hearing things that are not real; fainting; seizures; coma; stopping breathing.
  • Sexual problems: Taking antidepressants like TRINTELLIX may cause sexual problems. Symptoms in males may include: delayed ejaculation or inability to have an ejaculation, decreased sex drive, or problems getting or keeping an erection. Symptoms in females may include: decreased sex drive, or delayed orgasm or inability to have an orgasm. Talk to your healthcare provider if you develop any changes in your sexual function or if you have any questions or concerns about sexual problems during treatment with TRINTELLIX.

The most common side effects of TRINTELLIX include:

  • nausea
  • constipation
  • vomiting

These are not all the possible side effects of TRINTELLIX. Tell your doctor if you have any side effect that bothers you or does not go away.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

What is TRINTELLIX (vortioxetine)?

TRINTELLIX is a prescription medicine used in adults to treat a certain type of depression called Major Depressive Disorder (MDD).

There is a pregnancy registry for females who are exposed to antidepressants during pregnancy. The purpose of the registry is to collect information about the health of females exposed to antidepressants and their babies. If you become pregnant during treatment with TRINTELLIX, talk to your healthcare provider about registering with the National Pregnancy Registry for Antidepressants at 1-844-405-6185 or visiting online at https://womensmentalhealth.org/clinical-and-research-programs/pregnancyregistry/antidepressants/

For additional Important Safety Information, click here for Medication Guide, and discuss with your doctor.

This site is intended for use by U.S. residents ages 18 and older only.

TRINTELLIX is a trademark of H. Lundbeck A/S registered with the U.S. Patent and Trademark Office and used under license by Takeda Pharmaceuticals America, Inc.
TAKEDA and the TAKEDA logo are registered trademarks of Takeda Pharmaceutical Company Limited.

©2022 Takeda Pharmaceuticals U.S.A., Inc. All rights reserved. 1-877-TAKEDA-7 (1-877-825-3327).

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